Our Lab


Our Lab

Our Scientific Approach:

We employ cutting-edge genomics approaches to elucidate the role of T cells in immunohomeostasis and disease. We apply this knowledge to elucidate the cellular players and molecular circuitry that drive pathological changes in the skin in diseases such as skin cancer, cancer of skin immune cells, and autoimmune disease.

Currently, there is an unprecedented opportunity to study and modify T cells in the setting of disease.

The goal is to translate these findings to clinical trials. Learn more about recent publications from the lab.

Current Projects

  • T cell circuitry: We are combining traditional genetics with functional genomics to elucidate cellular circuitry in tissues and molecular circuitry within cells. These studies reveal novel tissue resident T cells and novel genes that modulate T cell fate, signaling and transcriptional programs.
  • Disease-Relevant Molecular Mechanisms: We are using human and animal models to determine how T cells contribute to disease pathogenesis. Currently, the primary foci are cancer and autoimmune or autoinflammatory diseases.
  • Clinical Translation: We are actively studying methods to translate our findings into clinically useful biomarkers and novel therapeutics.

We are looking for motivated, energetic postdoctoral fellows, graduate students, and bioinformaticians to join the Choi lab. If you are interested, please contact us:

Jaehyuk Choi
Northwestern University Feinberg School of Medicine
303 East Superior St.
Chicago, IL 60611

“Cancer was not disorganized chromosomal chaos. It was organized chromosomal chaos.”
Siddhartha Mukherjee, The Emperor of All Maladies: A Biography of Cancer