Publications

CTCLs are inhibited by negative homeostatic pathways that constrain untransformed T cells. In this case, T cell exhaustion is a powerful tumor suppressor. PD1 deletions reverse T cell exhaustion leading to more aggressive disease phenotypes in vitro and in vivo.


2021

  • Lee, K, Evans MG, Yang L, Ng Spencer, Snowden C, Khodadost M, Brown RA, Trum NA, Querfeld C, Doan LT, Song J, Zhang H, Wood GS, Wada DA, Shnmugam V, Haun PL, Duncan L, Guitart J, Weinstock DM, Nardi V*, Choi J*. Primary Cytotoxic T Cell Lymphomas Harbor Recurrent Targetable Alterations in the JAK-STAT Pathway. (2021) Blood. [in minor revisions] *co-corresponding authors
  • Nihal M, Wu J, Stonesifer CJ, Daniels J, Choi J, Geskin L, Rook AH, Wood GS. Epigenetic Regulation of Apoptosis in Cutaneous T-cell Lymphoma: Implications for Therapy with Methotrexate, JAK Inhibitors, and Resveratrol. (2021) J Invest Dermatol. [in press]
  • Qian Y, Arellano G, Ifergan I, Lin J, Snowden CK, Kim T, Thomas JJ, Law C, Balabanov RD, Guan T, Kaech SM, Miller SD, Choi J*. ZEB1 Promotes Pathogenic Th1 and Th17 Cell Differentiation in Autoimmune Disease. (2021) Cell Reports. [in press] *Co-corresponding authors
  • Nguyen QT, Kim D, Iamaswat S, Le HT, Kim S, Qiu KT, Hinds TD, Baseley P, O’Shea JJ, Choi J, Asosingh K, Erzurum SC, Min B. Steroid responsiveness in Foxp3+ regulatory T cells determines steroid responsiveness in allergic airway inflammation in mice. (2021) J Immunol. Cutting Edge [epub ahead of print]
  • Park J, Daniels J, Wartewig T, Ringbloom KG, Martinez-Escala ME, Choi S, Thomas JJ, Doukas PG, Yang J, Snowden C, Law C, Lee Y, Lee K, Zhang Y, Conran C, Tegtmeyer K, Mo SH, Pease DR, Jothishankar B, Kwok PY, Abdulla FR, Pro B, Louissaint A, Boggon T, Sosman J, Guitart J, Rao DA, Ruland J*, Choi J*. Integrated Genomic Analyses of Cutaneous T Cell Lymphomas Reveal the Molecular Bases for Disease Heterogeneity.(2021) Blood. [epub ahead of print] *co-corresponding authors
  • Zaidi AJ, Choi J, Nardone B, Liszewski W. Differences in Merkel cell carcinoma survival by site of primary presentation. J Am Acad Dermatology. 2021 Apr 18:[epub ahead of print]
  • Zhou XA, Yang J, Ringbloom KG, Martinez-Escala ME, Stevenson KE, Wenzel AT, Fantini D, Martin HK, Moy AP, Morgan EA, Harkins S, Paxton CN, Hong B, Andersen EF, Guitart J, Weinstock DM, Cerroni L, Choi J*, Louissaint A*. Genomic landscape of cutaneous follicular lymphomas reveals 2 subgroups with clinically predictive molecular features. Blood Advances. 2021 Feb 9;5(3):649-661. PMID: 33560380. *Co-Corresponding Author 

Figure 1.Proposed model of cell of origin driving disease pathogenesis in PCGDTL. Epidermal/dermal PCGDTL derives from the Vd1 cell whereas panniculitic PCGDTL derives from the Vd2 cell.


2020


Figure 1. Clinical Course of Patient with DRESS Treated with Tofacitinib. 

2019


Figure 1. (A) Mutational Burden of Skin and Selected Non-Skin Cancers for Comparison. (B) Schema Depicting Model of Convergent Development of MCPyV- and MCPyV+ MCC. 

2018


Figure 1. Identification of Genes that Drive T Cell Lymphomagenesis. 

2017


Figure 1. Identification of Viral and Non-Viral Neoantigens in Merkel Cell Carcinoma.

2016


Figure 1. Identification of the Genomic Landscape of CTCL. 

2015

  • Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, Bjornson RD, Maman Y, Wang T, Tordoff J, Carlson K, Overton JD, Liu KJ, Lewis JM, Devine L, Barbarotta L, Foss FM, Subtil A, Vonderheid EC, Edelson RL, Schatz DG, Boggon TJ, Girardi M, Lifton RP. Genomic landscape of cutaneous T cell lymphoma. Nat Genet. 2015 Sep;47(9):1011-9. doi: 10.1038/ng.3356. Epub 2015 Jul 20. PubMed PMID: 26192916; PubMed Central PMCID: PMC4552614.
  • Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC. A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT. J Cutan Pathol. 2015 Feb;42(2):108-17. doi: 10.1111/cup.12444. Epub 2014 Dec 11. PubMed PMID: 25407517; PubMed Central PMCID: PMC4470704.

2014


2011


2008

  • Lansigan F, Choi J, Foss FM. Cutaneous T-cell lymphoma. Hematol Oncol Clin North Am. 2008 Oct;22(5):979-96, x. doi: 10.1016/j.hoc.2008.07.014. Review. PubMed PMID: 18954747.

2007


2006


2005


2004


2003


For a complete list of publications, please click on the following link:

http://www.ncbi.nlm.nih.gov/sites/myncbi/jaehyuk.choi.1/bibliography/45286647/public/?sort=date&direction=ascending


“Grit is passion and perseverance for very long-term goals. Grit is having stamina. Grit is sticking with your future, day-in, day-out. Not just for the week, not just for the month, but for years. And working really hard to make that future a reality. Grit is living life like it’s a marathon, not a sprint.”

Angela Lee Duckworth, Grit