Fig. 1. We utilize genomics to identify the genetic basis by which Merkel cell carcinoma cells can be targeted by the patient’s own immune system.
Goal: The goal is to elucidate T cell circuitry, identify disease relevant molecular mechanisms, and develop clinically relevant biomarkers and therapeutics.
Approach: To accomplish these goals, our lab employs two scientific approaches to investigate T cell biology.
- We utilize genomics and orthogonal high dimensional assays to elucidate the molecular features of each patient’s cancer. We then perform iterative analyses across a disease cohort to identify molecular features that occur more often than expected by chance. We then functionally validate the putative drivers using human and mouse models.
- We interrogate patient samples to identify molecular features that predict disease prognoses and responses to therapies.
- Coming soon!
- The goal is to identify novel potentially curative therapeutic strategies for otherwise intractable diseases.
- We leverage these discoveries to launch clinical trials. Coming soon.
- We integrate human genetics, functional genomics, and orthogonal high dimensional assays to resolve the cellular and genetic mechanisms governing immune homeostasis.
- These approaches have led to the following discoveries:
- We leverage these discoveries to identify novel therapeutic strategies for inflammatory diseases.
“In God we trust, all others [must] have data.”
― Bernard Fisher