Fig. 1. We utilize genomics to identify the genetic basis by which Merkel cell carcinoma cells can be targeted by the patient’s own immune system.
Our lab has two areas of research focus.
- We utilize genomics and orthogonal high dimensional assays to elucidate the molecular features of each patient’s cancer. We then perform iterative analyses across a disease cohort to identify molecular features that occur more often than expected by chance. We then functionally validate the putative drivers using human and mouse models.
- We interrogate patient samples to identify molecular features that predict disease prognoses and responses to therapies.
- The goal is to identify novel potentially curative therapeutic strategies for otherwise intractable diseases.
- We utilize genomics and orthogonal high dimensional assays to resolve the cellular and genetic mechanisms governing immune homeostasis.
- These approaches have led to the following discoveries:
- Novel skin-resident cells (coming soon!)
- Novel molecular mechanisms governing T cell activation
- Novel molecular mechanisms governing T cell differentiation
- We leverage these discoveries to identify novel therapeutic strategies for inflammatory diseases and cancer.
“In God we trust, all others [must] have data.”
― Bernard Fisher