Figure 1. Circos plots of somatic point mutations and copy number mutations identified in cutaneous T cell. lymphoma. Point mutations are indicated by black triangles; deletions, light blue boxes; amplifications, red boxes; translocations, royal blue lines; intrachromosomal rearrangements, green lines.
Our Scientific Approach
We employ cutting-edge genomics approaches to elucidate the immunobiology of the skin during health and disease. We apply this knowledge to elucidate the cellular players and molecular circuitry that drive pathological changes in the skin in diseases such as skin cancer, cancer of skin immune cells, and autoimmune disease. The goal is to translate these findings to clinical trials. Learn more about recent publications from the lab.
- Gene Discovery: We use cutting edge approaches to identify the genetic/epigenetic bases of other inherited and acquired skin diseases and cancers.
- Molecular Mechanisms: We use human and animal models to determine how mutations we discovered affect disease pathogenesis.
- Clinical Translation: We are actively studying methods to translate our findings into clinically useful biomarkers and novel therapeutics.
We are looking for motivated, energetic postdoctoral fellows, graduate students, and bioinformaticians to join the Choi lab. If you are interested, please contact us:
Northwestern University Feinberg School of Medicine
303 East Superior St.
Chicago, IL 60611
“Cancer was not disorganized chromosomal chaos. It was organized chromosomal chaos.”
― Siddhartha Mukherjee,